Jag följer en harvard-professor vid namned David Sinclair. (Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School) En man som dedikerat sitt liv till att forska om hur vi kan förlänga livet och fortfarande står i fronten för denna forskning.
Han utvecklar i en intervju att de redan kan upphäva och vända åldrandet på möss och går in på djupet, jag citerar en del från intervjun nedan så ni slipper titta.
Vi pratar nu om saker som vi trodde var omöjliga som börjar bli möjliga på riktigt där vi i labb kan se att man kan förlänga livslängd och till och med återställa ålder i delar av kroppen.
Frågeställningen blir då, har de som satsar på Die With Zero - FIRE verkligen tillräckligt med pengar?
Om man planerat att man ska leva till 80,90 och har ett sparande som leder till att man kan ta ut en viss mängd pengar fram till döden och dö på noll, men vetenskapen under den tiden gör framsteg så att man lever till 100, 110 eller 150 så ändras den kalkylen avsevärt.
Helt enkelt bör man fundera på att ändra rådet? den som sparat till 60 och börjar ta ut för Die With Zero som sedan finner att den kommer att leva till 120 vid 80 års ålder och redan gjort av med större delen av kapitalet kommer inte ha råd med samma livsstil som hen hade velat ha. Bör vi då råda de som vill leva Die With Zero-FIRE att se till att ha ett sådant stort kapital att de kan ta ut den mängd pengar de vill ha utan att summan går ner över tid?
Delar citat från intervjun nedan:
We published a year ago on the cover of nature magazine that we can reset the age of a complex tissue. We chose the mouse’s eye, we let mice get old and blind and we reprogrammed their eye using these three genes called O.S.K for short and turned the age back 80% and they became able to see again.
So what we’re talking about is how we found that there’s a reset switch in the body to be young again and information in the body to be young is still there so theoretically you could take someone who’s a hundred years old and reset their body to be young again.
Now the exciting thing is we’ve been doing clinical trials or preclinical trials and there’s no apparent downside to this yet.
We first made this discovery about three years ago, since then we’ve been doing the hard work which is to figure out if it is safe enough to put into humans and we’re now testing it in non-human primates just to see if it’s safe and if all goes well in the next two years we’ll hopefully cure blindness.But it gets better, the eye was just something we chose I didn’t think it would work any better in the eye in fact I thought it probably would work worse but we found that there’s a universal reset switch so you can reset different parts of the body, we can reset the skin, we’ve also shown that we can reset muscle.
So we are basically turning on an embryonic program in older people or middle aged in their cells and in mice and they get young again
What does this mean?
This means one day it’s going to be possible to reset the age of the body.
We have done that.
We have done that in mice now the question is how soon can we get it into ourselves.We’re at a point now where we are able to control aging pretty easily in my lab, we can drive aging forward and backwards in mice at will, aging is malleable now that we have an understanding of how it’s controlled and what causes it and we even have mini brains in the lab
I can make organs, mini organs from a human and test drugs on them.
We grow these mini brains in the lab and we got them from people that are predisposed to Alzheimer’s and from those who are not. We have a way to age those brains so that they’re now 80 years old even though they’re only a few months old and they lose the ability to fire electrically, they become demented.
Then what we do is we have the system to turn on those three embryonic genes O.S.K and those brains go back in age, but he’s the cool thing, Alzheimer’s goes away, the electrical activity comes back.
Now we do this in a mouse, we make the mouse older, just let them age out, we accelerate it and we’ve been now reversing the age of those brains in the mice and you can guess what happens, they get their memory and ability to learn back.